Religion is very important to the Chickasaw people. Our history often included significant events and meetings at our churches. Some of the churches such as Yellow Spring, Seeley Chapel, Sandy Creek Church, Blue Baptist, High Hill, Freedom Fellowship, Mitchel Memorial, First Indian Baptist, in Tishomingo and in Ada, Pennington Methodist Church and Boiling Springs have had Chickasaw congregations for many years.

The Boiling Springs United Methodist Church, which consists of members of Chickasaw/Choctaw descent, recorded the Choctaw Hymn CD in 2002 in an effort to help preserve heritage and serve as an outreach ministry.

One of the most significant and historic sites in the Chickasaw Nation is Seeley Chapel. Seeley Chapel was first the site of a neighborhood school. Later, the site became a place of worship and many political meetings for the "fullbloods" and elected leaders. One of the most significant events was on October 26, 1963 when Governor Overton James was formally sworn into office. In June 2002, the Chickasaw Historical Society unveiled and dedicated a beautiful granite marker, forever identifying Seeley Chapel as a prominent site in Chickasaw history.